The Opportunity
Esco Lifesciences Group is Singapore’s most globalized life sciences company, with annual revenues close to SGD 200M and global operations in over 42 locations and 26 direct countries across North America, Europe, Asia, Oceania.
Esco Aster Pte Ltd is an affiliate of Esco Lifesciences Group and was first incorporated in 2017.
Esco Aster is a contract research development and manufacturing organization founded and deeply rooted by scientists enabling fellow scientists to translate their bench work into commercially available products at affordable prices.
Our scientific work is in emerging and frontier biology utilizing cells as a final product or deriving products from cells which often we use cells as the factory to derive our target product.
Our first commercial breakthrough success is Esco Aster is commercially first in class being first in the world to be certified for cultivated/cell-based meat to FSSC 22000 and by a competent food regulatory body.
We are first in the region to operate an end-to-end integrated full cell line creation/immortalization or engineered cell line, cell culture process development, analytical development for stem cells and exosomes with full cGMP Capabilities from Drug Substance and small-scale fill & finish for final Cell Therapy Product.
The work we do creates a remarkable and lasting impact on our world. We offer you an opportunity to be part of this exciting journey to own your career and firsthand exposure to new emerging modalities supporting translational sciences.
The Scope
You will be part of Esco Aster's MSAT team and contribute to the overall site mission and objectives. You will ensure Commissioning Qualification and Validation (CQV) activities and tasks are planned and executed in an efficient and compliant manner, while adhering to GxP standards. You will work with the Leadership team of MSAT to develop a continuous improvement mindset and engage in teamwork with cross-functional departments.
Primary work location: Ayer Rajah Crescent, Singapore
Job Responsibilities
· Perform risk-based commissioning, qualification and validation of pharmaceutical and biopharmaceutical equipment, utilities, facilities and processes.
· Develop validation protocols and reports that fulfil regulatory requirements and industry best practices.
· Assist in developing User Requirements Specification documents.
· Prepare design review and design qualification documents at the initial design stage to align with specifications.
· Generate protocols and execute field work related to Commissioning (FAT, SAT), Installation & Operational Qualification (IOQ).
· Prepare and execute FMEA and validation activities pertaining to Performance Qualification (PQ), Computerized System Validation (CSV), Cleaning Validation, Thermal Validation and Transport Qualification, as required.
· Complete assigned CQV tasks according to planned schedule, budget, safety and engineering standards.
· Coordinate with internal teams (manufacturing, engineering, quality etc.) to achieve CQV objectives.
· Coordinate and manage external parties, primarily vendors and contractors to achieve CQV objectives.
· Investigate deviations and write deviation reports and findings.
· Support Engineering and Facilities functions as needed.
· Undertake tasks assigned by leaders as and when appropriate.
Requirements
· Degree and/or Diploma in Engineering/Science or related studies.
· Minimum of 1-3 years’ experience in pharmaceutical/biopharmaceutical manufacturing facility.
· Familiar with working in a GxP environment and keeping up to date with current GxP, with flexibility to change as needed due to new regulatory requirements and technologies, as relevant for clinical and commercial supply.
· Good knowledge of GxP, GDP, CQV approaches including Validation Lifecycle approach (URS, DQ, FAT/SAT, IOQ, CSV, Cleaning/ Thermal Validation etc.), regulatory requirements and best industry practices.
· Competent in technical writing and presentations.
· Proficient in MS Office Suite (Microsoft Word, PowerPoint, Excel).
· Able to work independently, self-starter, self-motivated and task oriented.
· Good communication skills and able to openly communicate and escalate any relevant issues.
· Strong team player to work with both internal and external stakeholders.
· Develop positive relationship with a strong set of interpersonal skills.
· Prepared to travel and reside abroad to ensure the successful execution of external projects, if required.
Interested candidates, please submit a Cover Letter and CV to jobs@escoaster.com.Only shortlisted candidates will be contacted.
The OpportunityEsco Lifesciences Group is Singapore’s most globalized life sciences company, with annual revenues close to SGD 200M and global operations in over 42 locations and 26 direct countries across North America, Europe, Asia, Oceania.
Esco Aster Pte Ltd is an affiliate of Esco Lifesciences Group and was first incorporated in 2017.
Esco Aster is a contract research development and manufacturing organization founded and deeply rooted by scientists enabling fellow scientists to translate their bench work into commercially available products at affordable prices.
Our scientific work is in emerging and frontier biology utilizing cells as a final product or deriving products from cells which often we use cells as the factory to derive our target product.
Our first commercial breakthrough success is Esco Aster is commercially first in class being first in the world to be certified for cultivated/cell-based meat to FSSC 22000 and by a competent food regulatory body.
We are first in the region to operate an end-to-end integrated full cell line creation/immortalization or engineered cell line, cell culture process development, analytical development for stem cells and exosomes with full cGMP Capabilities from Drug Substance and small-scale fill & finish for final Cell Therapy Product.
The work we do creates a remarkable and lasting impact on our world. We offer you an opportunity to be part of this exciting journey to own your career and firsthand exposure to new emerging modalities supporting translational sciences.
Join us as we redefine BioSolutions for One World and One Health for the current and future generations to come.Esco Aster.
One World Biosolutions for One Health.
Who we’re looking forPhysical / Mental Requirements / Work Environment:Strong leadership and communication skills.Ability to stay focused under pressure and adapt proactively.Critical thinker with a systematic and meticulous approach.Curious and self-motivated to stay updated on cell/gene therapy and emerging technologies.Committed to safety, quality, compliance, and timely delivery.Cleanroom and GMP manufacturing settings.Requires wearing full gowning/PPE.May engage in overtime during campaign activities or urgent troubleshooting.
The ScopeTo support Quality functions from GMP readiness to ongoing compliance for cell and gene therapy manufacturing in a cGMP environment, ensuring adherence to global regulatory standards through oversight of operations, documentation, and quality systems.
Primary work location: Ayer Rajah Crescent, Singapore
Job ResponsibilitiesInitiate, investigate, and close deviations, and manage CAPA processes including effectiveness checks.Review, assess, and manage change controls related to materials, equipment, processes, and documentation.Perform thorough review of executed batch manufacturing records, critical logbooks, and associated documentation.Provide real-time QA support on the manufacturing floor during production, aseptic operations, and changeovers.Review, revise, and approve GMP documentation including Standard Operating Procedures (SOPs), Master Batch Records (MBRs), and work instructions.Conduct gap assessments of processes and procedures against current GMP and regulatory expectations.Support internal and external audits including preparation, hosting, documentation retrieval, and response drafting.Participate in continuous improvement initiatives and cross-functional project teams to enhance quality systems and operational efficiency.Collaborate with manufacturing, QC, validation, and engineering teams to ensure timely execution of quality deliverables.Support inspection readiness activities and promote a strong culture of compliance and quality awareness.Train and mentor operations staff on quality procedures and best practices as needed.Utilize electronic Quality Management Systems (eQMS) to manage quality workflows and records.Support Quality Control function as needed, including review of QC documentation, data trending, and investigations.Undertake other tasks as assigned by the management based on project needs.
RequirementsBachelor’s or Master’s in Life Sciences, Biotechnology, Pharmacy or equivalent.3–5 years of GMP QA/Quality experience, preferably in Cell & Gene Therapy, Biologics, or ATMP manufacturing.Experience in working in cell and gene therapy manufacturing is an added advantageStrong knowledge of cGMP, GDP, FDA/EMA standards, PIC/S, ICH Q7/Q9, Annex 1, data integrity principles.Proficiency with quality systems (deviation, CAPA, change control, document control, batch release etc).Familiar with eQMS, and electronic document systems.Excellent communication, analytical, problem‑solving, and collaborative skillsAble to work independently and under tight timelines; experience in Q&A shop‑floor oversight.Proficient in MS Office Suite (Microsoft Word, PowerPoint, Excel).Strong team player with a strong set of interpersonal skills.Excellent written and verbal communication skills.Experience with SAP/MES/LIMS, CQV/CSV (ISPE, GAMP 5, 21 CFR Part 11, EU Annex 11), and analytical or microbiological testing (including method validation and environmental monitoring) is an added advantage.
Apply now by submitting a Cover Letter and CV to jobs@escoaster.com.Only shortlisted candidates will be contacted.
The OpportunityEsco Lifesciences Group is Singapore’s most globalized life sciences company, with annual revenues close to SGD 200M and global operations in over 42 locations and 26 direct countries across North America, Europe, Asia, Oceania.
Esco Aster Pte Ltd is an affiliate of Esco Lifesciences Group and was first incorporated in 2017.
Esco Aster is a contract research development and manufacturing organization founded and deeply rooted by scientists enabling fellow scientists to translate their bench work into commercially available products at affordable prices.
Our scientific work is in emerging and frontier biology utilizing cells as a final product or deriving products from cells which often we use cells as the factory to derive our target product.
Our first commercial breakthrough success is Esco Aster is commercially first in class being first in the world to be certified for cultivated/cell-based meat to FSSC 22000 and by a competent food regulatory body.
We are first in the region to operate an end-to-end integrated full cell line creation/immortalization or engineered cell line, cell culture process development, analytical development for stem cells and exosomes with full cGMP Capabilities from Drug Substance and small-scale fill & finish for final Cell Therapy Product.
The work we do creates a remarkable and lasting impact on our world. We offer you an opportunity to be part of this exciting journey to own your career and firsthand exposure to new emerging modalities supporting translational sciences.
Join us as we redefine BioSolutions for One World and One Health for the current and future generations to come.
Esco Aster.One World Biosolutions for One Health.
Who we’re looking forPhysical/Mental Requirements/Work Environment· Ability to understand protocols, technical reports and technology transfer documents.· Ability to understand standard operating procedures and other related documents.· Able to commit to weekend work when needed, off in lieu will be given for work on public holidays.· Repetitive motions due to certain laboratory techniques.· Good Understanding of Aseptic Techniques.· Work performed in a clean room environment wearing PPE.· Ability to define problems, collect data, establish facts and draw conclusions.· Ability to focus regardless of circumstances and stress induced pressure.· Ability to take proactive approach.· Meticulous and systematic.· Commitment to continuous learning and staying updated with industry best practices.· Have a strong focus on safety, quality and timeliness.· Have strong critical thinking skills.
Job ResponsibilitiesSample and QC Process Management:· Ensure all QC sample management, testing, including process validation, cleaning, raw materials, stability samples, water samples, etc., are planned and executed on time.· Prioritize and plan all testing activities to support processing schedules.· Plan QC testing on a FIFO basis to eliminate backlog and meet internal QC KPIs.· Plan work assignments for all QC analysts based on the production plan.· Support future setup of central QC lab for all BioSolutions within Esco Aster.
Leadership and Team Management:· Lead the implementation of the Laboratory Information Management System (LIMS).· Lead Quality Control SOP implementation.· Collaborate with the Analytical Development Team and manage QC Analytical, Microbiology Team to manage the revision and/or change control of QC documents as needed.· Ensure new Analysts and Specialists are trained appropriately.· Supervise, develop, engage, and motivate a young and driven team of QC Team Members.· Manage the routine operations of the QC lab, ensuring business delivery at the right quality, cost, and speed.· Able to build and lead across functional department consisting of different QC functions and supervisors / deputies / subject matter.
Operational Oversight:· Oversee several sub-teams such as sample management, reference management, regulatory management, and QC instrument and equipment management.· Lead the team to comply with internal requirements in all aspects through end-to-end quality control system oversight.· Ensure all activities in the QC team are performed in compliance with cGMP, data integrity, and EHS requirements.· Keep up to date with the latest trends in Quality Controls Tools.
Training and Development:· Oversee the training, evaluation, and management of staff in the QC lab, including coaching, developing, and supporting them to reach their full potential.
Regulatory Compliance:· Manage GMP audits from regulatory authorities and clients, respond to audit reports, and create CAPAs as applicable.· Support analytical method transfer activities.· Author and review OOS/OOT and Deviation investigations for approval, maintaining investigation records in accordance with company policies.
Cross-Departmental Collaboration:· Participate in Quality Risk Assessment Programs.· Provide input and expertise on QC testing and practices for all departments.· Serve as the QC representative for all customer and agency audits and support the audit of all 3rd party contract facilities.· Oversee the management of Sample and Controlled Substance inventories.· Provide technical support and advice on QC matters to other areas within the site: Production, Procurement, Supply Chain, Warehouse, and Process Developments.· Work with Analytical Sciences and Technology (ASAT) to internal or external tech transfer from developed protocols from Analytical Development to Quality control including overseeing method verification, qualification, and validation activities.
Compliance Management:· Participate in self-inspection and support client audits.· Manage compliance tasks to ensure the Quality Control department is current and compliant.· Maintain purchase orders, cost centers, and budgets for the QC department.· Manage implementation and adherence to all applicable SHE and cGMP regulations.· Support and oversee 3rd party test labs and ensure test labs are qualified per our QMS.· Perform calibration and maintenance of QC laboratory equipment working with our CMMS and as per Iso 17025 standards and relevant GLP standards.· Support/ oversee QC laboratory equipment/system qualification.The job function listed is not exhaustive and shall also include any responsibilities as assigned by the Supervisor and Management from time to time to support GMP activities.
Requirements· Bachelor’s degree in life sciences with minimum of 5 years of experience in Quality Control within highly regulated cGMP pharmaceutical industry. Experience is Biologics and ATMPs (i.e. Cell and Gene) is an added advantage.· Candidates with experience in ATMPs (Cell & Gene) manufacturing are highly preferred but not mandatory.· Familiar and keeping up to date with current GMP and applicable GxP regulations and standards; experience with regulatory requirements such as Singapore/HSA, US/FDA, EU/EMEA, etc.· Good understanding of GMP requirements in release testing (Potency, Identity, Content, Impurities, Microbiological safety assays).· Experience in HPLC, Flow Cytometry, ELISA, dPCR/PCR, Assays and method qualification.· Proficient in MS Office Suite (Microsoft Word, PowerPoint, Excel).· Strong analytical skills and the ability to interpret data to drive decisions and improvements.· Able to work independently, self- starter, self-motivated and task oriented.· Good communication skills and leadership skills to effectively collaborate with cross-functional teams.· A thorough understanding of the principles and management of cGMP compliance, and a strong quality mindset.· Must be able to work in a team as well as independently.· Proven leadership and team management skills.· Excellent communication and organizational skills.· Experience with LIMS and other laboratory management systems.· Experience in Laboratory Equipment Qualification is an added advantage.· Will be able to commit 5 working days per week in a fixed pattern.
Apply now by submitting a Cover Letter and CV to jobs@escoaster.com.Only shortlisted candidates will be contacted.
The OpportunityEsco Lifesciences Group is Singapore’s most globalized life sciences company, with annual revenues close to SGD 200M and global operations in over 42 locations and 26 direct countries across North America, Europe, Asia, Oceania.
Esco Aster Pte Ltd is an affiliate of Esco Lifesciences Group and was first incorporated in 2017.
Esco Aster is a contract research development and manufacturing organization founded and deeply rooted by scientists enabling fellow scientists to translate their bench work into commercially available products at affordable prices.
Our scientific work is in emerging and frontier biology utilizing cells as a final product or deriving products from cells which often we use cells as the factory to derive our target product.
Our first commercial breakthrough success is Esco Aster is commercially first in class being first in the world to be certified for cultivated/cell-based meat to FSSC 22000 and by a competent food regulatory body.
We are first in the region to operate an end-to-end integrated full cell line creation/immortalization or engineered cell line, cell culture process development, analytical development for stem cells and exosomes with full cGMP Capabilities from Drug Substance and small-scale fill & finish for final Cell Therapy Product.
The work we do creates a remarkable and lasting impact on our world. We offer you an opportunity to be part of this exciting journey to own your career and firsthand exposure to new emerging modalities supporting translational sciences.
Join us as we redefine BioSolutions for One World and One Health for the current and future generations to come.Esco Aster.
One World Biosolutions for One Health.
Who we’re looking forPhysical / Mental Requirements / Work Environment:Strong leadership and communication skills.Ability to stay focused under pressure and adapt proactively.Critical thinker with a systematic and meticulous approach.Curious and self-motivated to stay updated on cell/gene therapy and emerging technologies.Committed to safety, quality, compliance, and timely delivery.Cleanroom and GMP manufacturing settings.Requires standing for long periods, working with sterile systems, and wearing full gowning/PPE.May engage in overtime during campaign activities or urgent troubleshooting.
The ScopeTo support the successful technology transfer, manufacturing execution, and commercial readiness of cell and gene therapy products in a cGMP environment, ensuring compliance, efficiency, and delivery excellence throughout the product lifecycle.
Primary work location: Ayer Rajah Crescent, Singapore
Job ResponsibilitiesCollaborate with internal/external stakeholders including QA, QC, MSAT, and commercial teams.Serve as Manufacturing Subject Matter Expert (SME) during audits, inspections, and due diligence.Involve in technology transfers (internal and external) and commissioning, qualification (C&Q) activities.Involve in Process Performance Qualification (PPQ), Aseptic Process Simulations (APS), and engineering/pilot runs.Support in cell culture, purification, and fill-finish operations in a single-use, aseptic, cGMP facility.Help in Ensuring readiness of raw materials, equipment, and team for autologous/ allogeneic campaigns.Ensure accurate and timely data entry in digital records, maintaining compliance with Good Documentation Practices (GDP).Author, review, and manage cGMP documentation: SOPs, batch records, risk assessments, protocols, etc.Support with manufacturing change control, deviation investigations and implement CAPAs.Support the implementation of electronic batch records.Undertake other tasks as assigned by the management based on project needs.
RequirementsMinimum Bachelor’s Degree in Biotechnology related disciplines, Chemical Engineering, Pharmaceutical Science or relevant discipline with 2 years or more experience in a cGMP/aseptic environment in biologics or cell and gene therapy.Minimum of 2-4 years in cGMP Biologics or cell and gene therapy manufacturing with relevant industry knowledge, hands on equipment experience and technical expertise. Upstream Manufacturing Process.Experience in Downstream and Upstream Manufacturing Process and/or Process Support services.Strong knowledge of cGMP practices and global regulatory requirements such as USFDA GMP, EU GMP, HSA GMP and PIC/S GMP.Proficient in MS Office Suite (Microsoft Word, PowerPoint, Excel).Able to work independently and task oriented in a dynamic environment.Strong team player with a strong set of interpersonal skills.Excellent written and verbal communication skills.Experience in working in cell and gene therapy manufacturing is an added advantage.
Apply now by submitting a Cover Letter and CV to jobs@escoaster.com.Only shortlisted candidates will be contacted.
Manufacturing Lead
The OpportunityEsco Lifesciences Group is Singapore’s most globalized life sciences company, with annual revenues close to SGD 200M and global operations in over 42 locations and 26 direct countries across North America, Europe, Asia, Oceania.
Esco Aster Pte Ltd is an affiliate of Esco Lifesciences Group and was first incorporated in 2017.
Esco Aster is a contract research development and manufacturing organization founded and deeply rooted by scientists enabling fellow scientists to translate their bench work into commercially available products at affordable prices.
Our scientific work is in emerging and frontier biology utilizing cells as a final product or deriving products from cells which often we use cells as the factory to derive our target product.
Our first commercial breakthrough success is Esco Aster is commercially first in class being first in the world to be certified for cultivated/cell-based meat to FSSC 22000 and by a competent food regulatory body.
We are first in the region to operate an end-to-end integrated full cell line creation/immortalization or engineered cell line, cell culture process development, analytical development for stem cells and exosomes with full cGMP Capabilities from Drug Substance and small-scale fill & finish for final Cell Therapy Product.
The work we do creates a remarkable and lasting impact on our world. We offer you an opportunity to be part of this exciting journey to own your career and firsthand exposure to new emerging modalities supporting translational sciences.
Join us as we redefine BioSolutions for One World and One Health for the current and future generations to come.Esco Aster.
One World Biosolutions for One Health.
Who we’re looking forPhysical / Mental Requirements / Work Environment:Strong leadership and communication skills.Ability to stay focused under pressure and adapt proactively.Critical thinker with a systematic and meticulous approach.Curious and self-motivated to stay updated on cell/gene therapy and emerging technologies.Committed to safety, quality, compliance, and timely delivery.Cleanroom and GMP manufacturing settings.Requires standing for long periods, working with sterile systems, and wearing full gowning/PPE.May engage in overtime during campaign activities or urgent troubleshooting.
The ScopeTo lead and manage the successful technology transfer, manufacturing execution, and commercial readiness of cell and gene therapy products in a cGMP environment, ensuring compliance, efficiency, and delivery excellence throughout the product lifecycle.Primary work location: Ayer Rajah Crescent, Singapore
Job ResponsibilitiesLead cross-functional biotechnicians and act as the bridge between process development and manufacturing.Collaborate with internal/external stakeholders including QA, QC, MSAT, and commercial teams.Serve as Manufacturing Subject Matter Expert (SME) during audits, inspections, and due diligence.Manage end-to-end technology transfers (internal and external).Involve in commissioning, qualification (C&Q) activities.Oversee execution of Process Performance Qualification (PPQ), Aseptic Process Simulations (APS), and engineering/pilot runs.Oversee cell culture, purification, and fill-finish operations in a single-use, aseptic, cGMP facility.Ensure readiness of raw materials, equipment, and team for autologous/allogeneic campaigns.Monitor, document, and troubleshoot manufacturing activities, ensuring compliance with SOPs and regulatory requirements.Author, review, and manage cGMP documentation: SOPs, batch records, risk assessments, protocols, etc.Lead manufacturing change control, deviation investigations and implement CAPAs.Lead the implementation of electronic batch records.Potentially leading a small team.Undertake other tasks as assigned by the management based on project needs.
RequirementsMinimum Bachelor’s Degree in Biotechnology related disciplines, Chemical Engineering, Pharmaceutical Science or relevant discipline with 2 years or more experience in a cGMP/aseptic environment in biologics or cell and gene therapy.Minimum of 4-6 years in cGMP Biologics or cell and gene therapy manufacturing with relevant industry knowledge, hands on equipment experience and technical expertise.Strong knowledge of cGMP practices and global regulatory requirements such as USFDA GMP, EU GMP, HSA GMP and PIC/S GMP.In-depth knowledge of the drug development process and commercialization pathways.Proficient in MS Office Suite (Microsoft Word, PowerPoint, Excel).Able to work independently and task oriented in a dynamic environment.Strong team player with a strong set of interpersonal skills.Excellent written and verbal communication skills.Experience in bringing cell and gene therapy products through clinical development to market is an added advantage.Proven track record in regulatory strategy and interactions is an added advantage.Proficient in MS Office Suite (Microsoft Word, PowerPoint, Excel).Able to work independently and task oriented in a dynamic environment.Strong team player with a strong set of interpersonal skills.Excellent written and verbal communication skills.
Apply now by submitting a Cover Letter and CV to jobs@escoaster.com.Only shortlisted candidates will be contacted.
Esco Lifesciences Group is Singapore’s most globalized life sciences company, with annual revenues close to SGD 200M and global operations in over 42 locations and 26 direct countries across North America, Europe, Asia, Oceania.
Esco Aster Pte Ltd is an affiliate of Esco Lifesciences Group and was first incorporated in 2017.
Esco Aster is a contract research development and manufacturing organization founded and deeply rooted by scientists enabling fellow scientists to translate their bench work into commercially available products at affordable prices.
Our scientific work is in emerging and frontier biology utilizing cells as a final product or deriving products from cells which often we use cells as the factory to derive our target product.
Our first commercial breakthrough success is Esco Aster is commercially first in class being first in the world to be certified for cultivated/cell-based meat to FSSC 22000 and by a competent food regulatory body.
We are first in the region to operate an end-to-end integrated full cell line creation/immortalization or engineered cell line, cell culture process development, analytical development for stem cells and exosomes with full cGMP Capabilities from Drug Substance and small-scale fill & finish for final Cell Therapy Product.
The work we do creates a remarkable and lasting impact on our world. We offer you an opportunity to be part of this exciting journey to own your career and firsthand exposure to new emerging modalities supporting translational sciences.Join us as we redefine BioSolutions for One World and One Health for the current and future generations to come.
Esco Aster.One World Biosolutions for One Health.
The ScopeYou will be part of Esco Aster’s Engineering team and contribute to the overall site mission and objectives. As a Project Engineer you will be a key support function in the end-to-end delivery of turnkey cleanroom projects—encompassing design coordination, construction, commissioning, and qualification—for clients in the pharmaceutical, semiconductor, healthcare, and research-laboratory sectors. Drawing on a strong engineering foundation (mechanical, electrical, or related), you will ensure each project is executed safely, on time, within budget, and in full compliance with ISO 14644, cGMP, and relevant local building codes. You will be the single point of accountability, steering multidisciplinary teams (HVAC, architectural, MEP, process utilities, controls, validation) and managing stakeholders ranging from client user groups to trade contractors and regulatory inspectors.
Primary work location: Ayer Rajah Crescent, Singapore (Office), and customer sitesReporting to: Head of Engineering
Job Responsibilities• Translate client URS into a definitive project scope, WBS, schedule (Primavera / MS Project), and cost baseline.• Lead constructability and design-for-cleanliness reviews (ISO class, airflow, pressurization, material & personnel flows).• Develop risk register and mitigation plans; obtain all permits and EHS approvals.• Interface with internal designers and external A/E partners to align layouts, HVAC zoning, filtration, finishes, and utility requirements.• Verify design meets regulatory requirements (FDA, EMA, PIC/S, USP /, ISO 14644-1/2/3/4/5).• Prepare bid packages, evaluate vendors for modular panels, FFUs, HEPA filters, process piping, and BMS/EMS systems.• Negotiate purchase orders and sub-contracts; track long-lead items to protect critical path.• Run daily/weekly site coordination meetings; enforce safety (LOTO, hot-work, clean-build protocols).• Manage field supervision, QA/QC inspections, punch lists, and change-order control.• Monitor schedule, productivity, earned-value, and cash flow; issue progress reports to internal leadership and clients.• Oversee IQ/OQ execution: airflow visualization, particle counts, differential-pressure mapping, temperature/humidity stratification, and recovery tests.• Coordinate with validation teams to close deviations and compile turnover package (DQ/IQ/OQ reports, as-built drawings, SOPs).• Secure client sign-off and occupancy certificates; organize training for operations staff.• Perform lessons-learned meetings and archive project documentation for ISO / cGMP audits.
Requirements· Degree/Diploma in Mechanical, Marine or Industrial Engineering with at least 5 years' relevant experience in the pharmaceutical or relevant industry.· Strong knowledge and hands on experience in execution of cleanroom construction projects, either as owner or as contractor.· Preferably 5–10 years managing clean-build or high-spec environments (ISO 5–8, Class 100–100 000) in pharma, fab, or healthcare· Solid grasp of airflow design, contamination-control, MEP coordination, BMS/EMS systems, and ISO/cGMP standards.· Expert knowledge of HVAC, central plant utility systems, Building management systems (BMS), Environment monitoring system (EMS) and clean room technology.· Familiar and understand GxP requirement for routine utilities and facility operation.· Preferable experience with start-up, commissioning and qualification of utilities equipment, including requirements for documentation and testing.· Able to work independently, self-starter, self-motivated and task oriented.· Excellent oral and written communication skills with high computer literacy.· Customer service orientated mindset and able to develop strong working relationships with internal customers.· Able to plan and ensure uninterruptable utility supplies to the end user for operational facilities A&A or upgrade· Familiar with industrial/engineering/regulatory best practices, codes and standards.· Willing to perform multiple and cross-functional tasks.
Interested candidates, please submit a Cover Letter and CV to jobs@escoaster.com.Only shortlisted candidate will be contacted.
The Opportunity Esco Lifesciences Group is Singapore’s most globalized life sciences company, with annual revenues close to SGD 200M and global operations in over 42 locations and 26 direct countries across North America, Europe, Asia, Oceania.
Esco Aster Pte Ltd is an affiliate of Esco Lifesciences Group and was first incorporated in 2017.Esco Aster is a contract research development and manufacturing organization founded and deeply rooted by scientists enabling fellow scientists to translate their bench work into commercially available products at affordable prices.
Our scientific work is in emerging and frontier biology utilizing cells as a final product or deriving products from cells which often we use cells as the factory to derive our target product.
Our first commercial breakthrough success is Esco Aster is commercially first in class being first in the world to be certified for cultivated/cell-based meat to FSSC 22000 and by a competent food regulatory body.
We are first in the region to operate an end-to-end integrated full cell line creation/immortalization or engineered cell line, cell culture process development, analytical development for stem cells and exosomes with full cGMP Capabilities from Drug Substance and small-scale fill & finish for final Cell Therapy Product.
The work we do creates a remarkable and lasting impact on our world. We offer you an opportunity to be part of this exciting journey to own your career and firsthand exposure to new emerging modalities supporting translational sciences.Join us as we redefine BioSolutions for One World and One Health for the current and future generations to come.
Who we’re looking forPhysical/Mental Requirements/Work EnvironmentAbility to understand protocols, technical reports and technology transfer documents.Ability to understand standard operating procedures and other related documents.Able to commit to weekend work when needed, off in lieu will be given for work on weekends and public holidays.Repetitive motions due to certain laboratory techniques.Good Understanding of Aseptic Techniques.Work performed in a clean room environment wearing PPE.Ability to define problems, collect data, establish facts and draw conclusions.Ability to focus regardless of circumstances and stress induced pressure.Ability to take proactive approach.Meticulous and systematic.Commitment to continuous learning and staying updated with industry best practices.Have a strong focus on safety, quality and timeliness.Have strong critical thinking skills.
Report To:Selected candidate will report to Quality Control Manager and others as assigned.
The ScopeYou will be part of Esco Aster's Quality Control team and contribute to the overall site mission and objectives. Specifically, you will contribute to microbial-related analytical testing and operational activities.Primary work location: Ayer Rajah Crescent, Singapore
Job ResponsibilitiesEstablishment of QC procedures (drafting and reviewing QC functional SOPs including QC testing SOPs).Responsible for Environmental monitoring (Viable and Non-Viable) of Cleanrooms, water and gases as per SOPs.Responsible for the Microbiological Testing of Water/Raw Material/in-process/ finished product / stability/validation/utility samples as per approved SOPs.Manage coordination and communication with external laboratories for Growth Promotion Testing, Sterility Testing, and Microbial Identification testing services.Support Sample Management functions.Ensure testing support media and consumable inventory timely manner to avoid delay in testing.Write, review and update standard operating procedures timely manner to operate EM and Microbiology operations and to ensure that specifications are in compliance with current GMP requirements/standards.Maintain data integrity and appropriate traceability.Responsible to identify OOS/OOT/Deviation and participate in Root Cause Analysis (RCA) and recommend corrective and preventive actions as applicable.General lab support including housekeeping, equipment maintenance, inventory of supplies, lab supplies ordering, management of glass wares, autoclaving etc. Responsible for microbiology lab and equipment/ instrument cleanliness.Responsible for disposition of samples upon confirmation.Collaborate with other functional teams in new processes/equipment/method qualifications.Explore and implement new technologies for rapid release such as rapid sterility testing.The job function listed is not exhaustive and shall also include any responsibilities as assigned by the Supervisor and QC Management from time to time to support GMP Facility.
RequirementsDegree with at least 3 years or Diploma with at least 5 years of experience in QC (Microbiology and Environmental Monitoring) from a highly regulated cGMP manufacturing environment (Biologics, Pharmaceuticals & ATMPs etc.).Candidates with experience in ATMPs (Cell & Gene) manufacturing are highly preferred but not mandatory.Ability to prioritize work and multitask.Knowledge and experience in QC laboratory operations and procedures, analytical test methods, troubleshooting and evaluation of analytical resultsThorough knowledge and understanding of current regulatory requirements of cGMP manufacturing.Good knowledge and understanding of Biologics manufacturing, aseptic operations and cleanroom behavior.Experience cell and gene therapy operations is an added advantage.Demonstrated ability to supervise, train, and manage technical staff.Demonstrated knowledge in Quality Control operations as it relates to QC testing, method validations and QC system implementation.cGMP regulations and audit experience in USFDA, EU and HSA etc.Will be able to commit 5 working days per week in a fixed pattern.Excellent communication, interpersonal and organizational skills.Ability to speak and write in English.
Apply now by submitting a Cover Letter and CV to jobs@escoaster.com.Only shortlisted candidates will be contacted.
The OpportunityEsco Lifesciences Group is Singapore’s most globalized life sciences company, with annual revenues close to SGD 200M and global operations in over 42 locations and 26 direct countries across North America, Europe, Asia, Oceania.
Esco Aster Pte Ltd is an affiliate of Esco Lifesciences Group and was first incorporated in 2017.
Esco Aster is a contract research development and manufacturing organization founded and deeply rooted by scientists enabling fellow scientists to translate their bench work into commercially available products at affordable prices.Our scientific work is in emerging and frontier biology utilizing cells as a final product or deriving products from cells which often we use cells as the factory to derive our target product.
Our first commercial breakthrough success is Esco Aster is commercially first in class being first in the world to be certified for cultivated/cell-based meat to FSSC 22000 and by a competent food regulatory body.
We are first in the region to operate an end-to-end integrated full cell line creation/immortalization or engineered cell line, cell culture process development, analytical development for stem cells and exosomes with full cGMP Capabilities from Drug Substance and small-scale fill & finish for final Cell Therapy Product.
The work we do creates a remarkable and lasting impact on our world. We offer you an opportunity to be part of this exciting journey to own your career and firsthand exposure to new emerging modalities supporting translational sciences.
Join us as we redefine BioSolutions for One World and One Health for the current and future generations to come.
Esco Aster.One World Biosolutions for One Health.
The ScopeYou will be part of Esco Aster’s Finance team and contribute towards the overall site mission and objectives. You will provide support in financial audits, reconciliation of accounts payable and other day-to-day finance office functions.
Primary work location: Ayer Rajah Crescent, Singapore
Job ResponsibilitiesPreparation and processing of accounting transactions for customers and vendors.Prepare and submit for approval of vendor payments.Reconciliation of accounts payable and any other balance sheet accounts as required.Monitor all payable/petty cash activities.Work with Sales team to post Sales orders and follow up on payment from customers.Work with Procurement team to review open Purchase Order and Prepayment schedule.Monthly AR/AP reporting requirements by Management.Prepare monthly schedule for reporting.Prepare monthly management account and consolidation reports.Perform stock count and processing of accounting transaction for inventories.Liaison with external auditors for annual audit and periodic reporting.Support forecasting and budgeting exercise.Handle ad-hoc duties assigned from time to time.
Key skills and competencies:Good command of both spoken and written English.Excellent interpersonal, communication & analytical skill.Proactive, flexible, reliable, self-motivated & organized.Must be a team player and contribute to team effort.Proficiency in software such as Microsoft Word, Excel, PowerPoint.Able to work independently, a self-starter, self-motivated and task oriented. A team player who is respectful.and supports/communicates constructively.Physical/Mental Requirements/Work Environment.Ability to work well under pressure.
Apply now by submitting a Cover Letter and CV to jobs@escoaster.com.Only shortlisted candidates will be contacted.
The Opportunity
Esco Lifesciences Group is Singapore’s most globalized life sciences company, with annual revenues close to SGD 200M and global operations in over 42 locations and 26 direct countries across North America, Europe, Asia, Oceania.
Esco Aster Pte Ltd is an affiliate of Esco Lifesciences Group and was first incorporated in 2017.
Esco Aster is a contract research development and manufacturing organization founded and deeply rooted by scientists enabling fellow scientists to translate their bench work into commercially available products at affordable prices.
Our scientific work is in emerging and frontier biology utilizing cells as a final product or deriving products from cells which often we use cells as the factory to derive our target product.
Our first commercial breakthrough success is Esco Aster is commercially first in class being first in the world to be certified for cultivated/cell-based meat to FSSC 22000 and by a competent food regulatory body.
We are first in the region to operate an end-to-end integrated full cell line creation/immortalization or engineered cell line, cell culture process development, analytical development for stem cells and exosomes with full cGMP Capabilities from Drug Substance and small-scale fill & finish for final Cell Therapy Product.
The work we do creates a remarkable and lasting impact on our world. We offer you an opportunity to be part of this exciting journey to own your career and firsthand exposure to new emerging modalities supporting translational sciences.
Join us as we redefine BioSolutions for One World and One Health for the current and future generations to come.
Esco Aster.One World Biosolutions for One Health.
Who we’re looking forPhysical/Mental Requirements/Work EnvironmentAbility to focusRepetitive motions due to certain laboratory techniques
Report To:Selected candidate will report to Quality Manager, or others as assigned.
The ScopeYou will be part of Esco Aster's Quality Control team and contribute to the overall site mission and objectives. Specifically, you will contribute to microbial-related analytical testing and operational activities.
Primary work location: Ayer Rajah Crescent, Singapore
Job ResponsibilitiesPerform routine/non-routine Environmental Monitoring and utility sampling for all required cleanroom and lab areas.Perform day-to-day general plate reading.Assists in day-to-day laboratory operation e.g. sample receiving, inventory control of laboratory supplies etc.Ensure proper record keeping and data management.Perform all tasks in accordance with cGMP regulations.Adhere to all site safety requirement.Perform routine laboratory housekeeping and proper waste disposal.Perform any other administrative/ ad-hoc duties as assigned.
RequirementsMinimally an ITE or Diploma holder in Microbiology, Biotechnology or related field.Minimum of 1 year of experience in Microbiological Testing or Environmental Monitoring is preferred.Comfortable working in a cleanroom environment with full PPE.Fresh graduates are strongly encouraged to apply.Proficient in MS Office Suite (Microsoft Word, PowerPoint, Excel).Strong interpersonal and communication skills, with the ability to work effectively both independently and as part of a team.Fluent in both spoken and written English.Demonstrates a committed and results-oriented mindset.Able to work efficiently under pressure in a fast-paced environment.
Apply now by submitting a Cover Letter and CV to jobs@escoaster.com.Only shortlisted candidates will be contacted.
The OpportunityEsco Lifesciences Group is Singapore’s most globalized life sciences company, with annual revenues close to SGD 200M and global operations in over 42 locations and 26 direct countries across North America, Europe, Asia, Oceania.Esco Aster Pte Ltd is an affiliate of Esco Lifesciences Group and was first incorporated in 2017.
Esco Aster is a contract research development and manufacturing organization founded and deeply rooted by scientists enabling fellow scientists to translate their bench work into commercially available products at affordable prices.
Our scientific work is in emerging and frontier biology utilizing cells as a final product or deriving products from cells which often we use cells as the factory to derive our target product.
Our first commercial breakthrough success is Esco Aster is commercially first in class being first in the world to be certified for cultivated/cell-based meat to FSSC 22000 and by a competent food regulatory body.
We are first in the region to operate an end-to-end integrated full cell line creation/immortalization or engineered cell line, cell culture process development, analytical development for stem cells and exosomes with full cGMP Capabilities from Drug Substance and small-scale fill & finish for final Cell Therapy Product.
The work we do creates a remarkable and lasting impact on our world. We offer you an opportunity to be part of this exciting journey to own your career and firsthand exposure to new emerging modalities supporting translational sciences.
Who we’re looking forPhysical/Mental Requirements/Work Environment· Ability to read, analyse and interpret scientific data and publications.· Ability to author or review protocols, technical reports and technology transfer documents.· Ability to author or review standard operating procedures and other related documents.· Ability to define problems, collect data, establish facts, and draw conclusions.· Ability to focus.· Repetitive motions due to certain laboratory techniques.· Ability to adapt and keep up with rapid changes in a fluid and dynamic environment as this is a rapidly evolving space.· Good understanding of cGMP and GDP requirement and practices.· Able to don in the cleanroom gowning and understand Aseptic Behaviour requirements.
The ScopeYou will be part of Esco Aster’s scientific division and contribute to the company’s CDMO mission and objectives. You will perform research and process development activities, in various projects and in collaboration with internal and external stakeholders, clients and partners.
Primary Work Location: Ayer Rajah Crescent, Singapore
Job Responsibilities· Work in the CDMO services as a part of the process team to develop processes for downstream unit operations for adherent cells (MSCs, iPSCs, Fibroblast, Epithelial cells, Vero, Hek293t) and derivatives (e.g. exosomes, nanovesicles, viral vectors, secreted viruses, mitochondria) as well as suspension cells for cultivated meat (mainly continuous centrifugation).· Design, plan, execute, and supervise experimental programs.· Analyse and interpret experiment data to draw scientific conclusions.· Perform wet lab and /or clinical trial material activities related to downstream unit operations and associated analytics.· Support and train subordinates on downstream techniques and operations.· Author or review protocols, technical reports, technology transfer and training documents with scientifically supported conclusions and recommendations.· Author or review standard operating procedures, instrument operating procedures and other lab related documents.· Assess and implement new processes and technologies in development scale, ultimately adapting to manufacturing operations.· Record and document data promptly and accurately maintaining data integrity.· Assist in non-routine lab duties and administrative activities including, and not limited to procurement, vendor assessment, people management, equipment maintenance, equipment calibration etc.· Support validation activities for new equipment as required.
Requirements· The successful candidate will have a Bachelor’s or Master’s degree or doctorate in Biological Sciences/(Bio)Chemical Engineering/Biological Engineering/Chemistry or related disciplines.· At least 3-5 years’ relevant experience in a life-sciences or related laboratory working with the downstream purification of stem cells/exosomes.· Experience in filtration (NFF and TFF) unit operations and bioprocess integration.· Knowledge of protein and molecular analyses, e.g., Western blot, qPCR, ELISA, flow cytometry etc.· Knowledge of technical or commercial operations in the manufacture of biological molecules is desirable.· Proficient in MS office- MS word, MS excel, PowerPoint.· Take initiatives, self-starter, research oriented, and able to work with minimum supervision.· Possess good communication and documentation skills.· Can contribute individually, as well as work efficiently in a dynamic team environment.
Apply now by submitting a Cover Letter and CV to jobs@escoaster.com. Only shortlisted candidates will be contacted.
